Recent breakthroughs in understanding the prostaglandin D2 (PGD2) receptor 1 (DP1) are paving the way for innovative ...

Researchers found that nearly 28% of hospitalized chronic liver disease patients with acute kidney injury had alcohol-related disorders, as did almost 60% with hepatorenal syndrome.

Discover how back pain can reveal kidney, liver, or lung problems. Learn the distinctive warning signs that differentiate ...

The results of this study demonstrate that HO-1 helps reduce hepatic fibrosis associated with NAFLD by modulating the SIRT1/TGF-β/Smad3 signaling pathway. Insights into the interactions between ...

This allowed us to identify genes and signaling pathways affected ... expressed genes and identified key pathways, including mitophagy, autophagy, ferroptosis, apoptosis, nonalcoholic fatty liver ...

Conversely, extracellular HMGB1 stimulates the expression of TNF-α and IL-6 via the TLR4/MyD88 and RAGE/p-JNK/p-ERK signaling pathways ... c-Jun N-terminal kinase; NAFLD, non-alcoholic fatty ...

The STING pathway also activates the NF-κB signaling cascade, further promoting inflammation. The STING pathway's role in NAFLD progression is multifaceted. High-fat diet-induced NAFLD has been ...

A severe form of fatty liver disease, called non-alcoholic steatohepatitis (NASH ... These should be investigated in the future because they signal the presence of additional autoimmune mechanisms ...

Blood kisspeptin levels change in human NAFLD patients and in a mouse model of NAFLD. “This work shows the kisspeptin receptor signaling pathway has a potential therapeutic role in NAFLD,” said ...

NAFLD is a kind of metabolic disordered disease, which is commonly associated with lipid metabolism, insulin resistance, oxidative stress, inflammation, and fibrogenesis, as well as autophagy. Growing ...