Rho-kinase is an effector of the active form of Rho. Many substrates of Rho-kinase have been identified, including myosin light chain (MLC), MLC phosphatase (MLCP), ezrin/radixin/moesin (ERM) family, ...

Research on new protein kinase targets and a range of potential disease indications has led to increasing interest in the development of small-molecule kinase inhibitors for the treatment of ...

neuro.wustl.edu Objective: To study the clinical and pathological correlations of neuromuscular patients with a high aldolase and normal creatine kinase (CK) in serum at presentation or during a ...

Here we demonstrated that INAD bound directly to the NINAC myosin III, yet the subcellular localization of NINAC was normal in inaD mutants. Nevertheless, the INAD binding site was sufficient to ...

Beijing National Research Center for Molecular Sciences, Key Laboratory of Molecular Nanostructure and Nanotechnology, Institute of Chemistry, Chinese Academy of Science, Beijing 100190, China Beijing ...

In the present study, we identified the phosphorylation sites in the kinase domain (KD), which are important ... kDa), ovalbumin (45 kDa), carbonic anhydrase (29 kDa), myosin regulatory light chain ...

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Myosin resting states play a critical role in regulating muscle ... equipped with a 20× objective (EVIDENT LUCPLFLN 20×/0.45), a THORLAB 365 nm light-emitting diode (LED) (M365LP1) controlled by a ...

However, the mechanism underlying this relationship remains unclear. This study aimed to investigate whether plasma neurofilament light chain (NfL) mediates the relationship between SSD and cognitive ...

scalable on-chain AI workloads. Meanwhile, StratoVM is transforming the Bitcoin DeFi (BTCFi) space with its EVM-compatible Layer-2 solution, enabling Ethereum-like smart contract capabilities on ...

Alice in Chains announced on Monday that they will cancel their forthcoming tour as well as any festival appearances. The decision came after a previous show was called off on May 8 because ...

LIM kinase, and mitogen-activated protein kinases. Important downstream targets include myosin II motors, actin capping and severing proteins, formins, profilin, cofilin, and the actin-related protein ...