Objective To determine whether the ratio of cerebrospinal fluid (CSF) immunoglobulin kappa to lambda light chains at time of multiple sclerosis (MS) diagnosis predicts disease progression and whether ...

Cardiac-specific loss of desmoplakin in mice in vivo (using a ventricular myosin light chain-2 Cre recombinase mouse line) resulted in early ultrastructural defects that were associated with the loss ...

Rho-kinase plays important roles in many intracellular signaling pathways. 7,8 Agonists bind to G-protein–coupled receptors and induce contraction by increasing both cytosolic Ca 2+ concentration and ...

Recent disruptions, transport network bottlenecks and rising concerns about economic security all point to the need to strengthen and diversify supply chains. However, simply re-localising all ...

A role for long chain myosin light chain kinase (MLCK-210) in microvascular hyperpermeability during severe burns. Shock 28 , 589–595 (2007). CAS PubMed Google Scholar ...

Abstract. Nodaviridae infections cause severe mortality in insects and fish, with nervous necrosis virus (NNV) posing significant threats to global fish populations. However, the host factors involved ...

Myosin light chain 3 serves as a receptor for nervous necrosis virus entry into host cells via the macropinocytosis pathway. Lan ... These revisions provide a clearer justification for the selection ...

Myosin makes the moves to keep cell processes humming along by Leah Shaffer, Washington University School of Medicine in St. Louis edited by Stephanie Baum , reviewed by Robert Egan ...

Safety and efficacy data from Nexicart-2, the first US trial of CAR-T in R/R light chain (AL) amyloidosis, Nxc-201. Charlotte Hughes , Aaron Seth Rosenberg , Mehrdad Abedi , Shahzad Raza , Jeffrey A.

Background: Oncogenic mutations and gene amplifications in the HER2 receptor tyrosine kinase are detected in approximately 2-4% and 1-5% of non-small cell lung cancers (NSCLC) in the US, respectively.

We have developed a novel method for quantifying protein isoforms, in both relative and absolute terms, based on MALDI-TOF mass spectrometry. The utility of the approach is demonstrated by quantifying ...