Lung cancer is the malignant tumor with the highest incidence and mortality rate in the world. With the in-depth research of ...

Relevance section written by JCO Associate Editor Thomas E. Stinchcombe, MD. Interestingly, even in the absence of this mutation, patients have exhibited similar survival benefits, suggesting a ...

This gene makes a protein, BCR-ABL, which causes CML cells to grow and reproduce out of control. BCR-ABL is a type of protein known as a tyrosine kinase ... t work or if the leukemia cells have a gene ...

Additionally, ongoing clinical trials of Bruton’s tyrosine kinase ... cells have distinct profiles during the embryonic, early post-natal, and adult stages (26). During embryonic development, ...

1Research Institute Children’s Cancer Center Hamburg, Hamburg, Germany. 2Department of Pediatric Hematology and Oncology, University Medical Center Hamburg, Hamburg, Germany.