We show here that the defect in activation of PI-3k/Akt by BCR/ABL ΔSH2 mutant ... proliferation and leukemogenesis in SCID mice. Incubation of cells with BCR/ABL tyrosine kinase inhibitor ...

CML, chronic myelogenous leukemia; PHC, Personal Health Care; TKI, tyrosine kinase inhibitor; USD, US dollars. Overall, the average annual part-D gross payment per 30 days of each TKI increased from ...

A team identified herpes virus saimiri, which infects the T cells of squirrel monkeys, as a source of proteins that activate pathways in T cells that are needed to promote T cell survival.

Relevance section written by JCO Associate Editor Thomas E. Stinchcombe, MD. Interestingly, even in the absence of this mutation, patients have exhibited similar survival benefits, suggesting a ...