However, the net impact of DG–CA3 dysfunction on in vivo hippocampal circuit function ... model of trisomy 21. Tc1 mice also show phenotypic alterations in hippocampus-dependent behavior ...

Song and her team found that in mice, the medial septum-to-hippocampus circuit works to keep DG stem cells in this normal, low-activity state. It acts like a brake on DG stem cell activation ...

Therefore, we investigated how pattern separation occurs in the hippocampus, a key memory circuit," says Peter Jonas ... in the hippocampal network in mice and rats. Now, Jonas used these real ...

The researchers could also determine which memory cells were active when the mice were placed ... cortex and the hippocampus is critical, because blocking the circuit connecting those two regions ...

Over the years, inhibitory interneurons have been posited as a major circuit element supporting ... in the CA3 and CA2 regions of the mouse hippocampus as the animals were awake and moving ...

First author Jean-Christophe Delpech and colleagues reported that misfolded tau rides this circuit into the hippocampus, where it promptly douses the activity of local neurons and hobbles associative ...

“When the same circuit performs more than one function ... They investigated how the mouse hippocampus switches from encoding the current location to recollecting a remote location. Here, mice ...

Gontier and colleagues found that as mice age, Tet2 levels in the hippocampus decline, as do the epigenetic tags Tet2 makes on DNA. Among the genes that lost these tags with age were those associated ...

Another unexpected behavioral observation was that mice whose D2 cells were artificially ... team is to show precisely how the dopamine-hippocampus circuit that modulates approach/avoidance ...