Patients with type 2 diabetes mellitus are at a higher risk of developing heart failure compared with the healthy population. In recent landmark clinical trials, sodium-glucose co-transporter 2 (SGLT2 ...

The cellular composition and underlying spatiotemporal transformation processes of subchondral bone in osteoarthritis (OA) remain unknown. Herein, various cell subsets from tibial plateau of patients ...

Morphine has been used to treat dyspnea for centuries, although the exact mechanism of action remains unclear. Opioids may diminish the chemoreceptor response to hypercapnia and hypoxia, ...

Chronic breathlessness is a disabling and distressing condition for which there is a growing evidence base for a range of interventions. Non-pharmacological interventions are the mainstay of ...

Introduction: Two Sides of the Same Leaf As awareness of plant-based alternatives to opioids grows, two names often surface in the conversation: kratom and its more potent derivative, ...

Objective To assess the efficacy of slow release oral morphine (SROM) as a treatment for opioid use disorder (OUD). Design Systematic review and meta-analysis of randomised controlled trials (RCTs).

A study led by University of Manchester epidemiologists has revealed which opioid painkillers are most likely to be ...

A group of researchers at Nara Women's University in this west Japan city has discovered that estrogen, a female hormone, is responsible for b･･･ ...

Background For the treatment of breathlessness in heart failure (HF), most textbooks advocate the use of opioids. Yet, meta-analyses are lacking. Methods A systematic review was performed for ...

When extended-release epidural morphine sulfate was administered at least 15 minutes after a test dose of lidocaine–epinephrine, no drug interaction occurred, and the liposomal technology ...

Furthermore, we demonstrated that the learned compensatory mechanism contributing to associative morphine tolerance requires an action of CCK at the CCK-B receptor in the L/BL amygdala. METHODS ...

In clinical settings, the dosing and differential diagnosis of the poisoning of morphine (MO) and codeine (CO) is challenging due to interindividual variations in metabolism. However, direct ...