Thus, this engineering approach will be a useful tool for design of IgG antibodies with tailored mode-of-action towards a specific target and indication. "Development of the next generation of ...

HK) presented the mechanism of action (MOA) research findings of its innovative bispecific antibody, AK132, targeting both Claudin18.2 (CLDN18.2) and CD47. AK132 is an asymmetric bispecific ...

a bispecific antibody targeting EGFR and LGR5, in the journal "Cancers." The study highlights the mechanism of action of petosemtamab, which is designed to combat cancer by blocking EGFR ligands ...

Interleukin (IL)-15 is a cytokine with different modes of action ... of clinical testing of humanized anti-IL-15 monoclonal antibodies. "IL-15 is an ambivalent cytokine, and understanding its ...

This mechanism of action opened up the floodgates ... The system is so named as it is known to “complement” the antibacterial action of antibodies, although it can also be activated in ...

Researchers at the Ragon Institute have made a significant discovery about how antibodies can directly enhance the body's ...

Though they are both multiple myeloma drugs with the same mechanism of action, Sanofi’s Sarclisa has had difficulty competing ...

Studies have reported that COVID-19 vaccines confer immune protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections by inducing antibody (Ab)-based humoral and T ...

However, the exact mechanism by which bulevirtide interacts ... the researchers first generated an antibody fragment that specifically recognises the NTCP-bulevirtide complex and makes it ...

The whole P-cadherin/antibody/drug complex is then sent to a structure called the lysosome to be broken down. “Our results establish an outside-in signaling mechanism that provides fundamental ...

Antibodies come in several subtypes ... DNase or their release was prevented by a substance with a novel mode of action, the immune defense remained intact. The researchers were able to ...