Abstract: Mitotic spindle assembly and chromosome segregation are dynamic ... Here we developed a computational spatially heterogeneous model of known biochemical interactions involved in spindle ...

Deleting the Aurora-A binding interface of CEP192 causes mitotic spindle defects reminiscent of Aurora-A inhibition ... these data validate the structural model of the two binding sites, and show that ...

Introduction: We have developed a risk-scoring model using gene expression levels related to mitotic spindle assembly (MSA) to predict the prognosis of liver cancer. Conclusion: Our research ...

Failures in chromosome segregation can occur if: the mitotic spindle is not properly assembled ... we are using this data to computationally model the networks that control G1 progression in order to ...

Current production Model 70 Featherweight in .308 Win. (top) and a 1982 Model 70 Featherweight XTR in .270 Win. (bottom). Tyler Freel We may earn revenue from the products available on this page and ...

F. Model illustrating the role of MT‐crosslinking activities of NuMA and HSET in uniform distribution of poleward forces across the mitotic spindle. Immunoblot analysis of the respective knockdown ...

The model simulates how the mitotic spindle assembles, how its microtubules attach to the kinetochore and the force required to pull two sister chromosomes apart. Building the simulation involved ...

A prototypical example of cytoskeletal remodeling is mitotic spindle assembly, where microtubules nucleate ... We develop a torque-balance model that describes this reorganization due to dynamic ...

2000). Yeast is the first model for which the mechanisms for spindle positioning have been described: an actin dependent and a dynein dependent pathway guide the process. In addition, the spindle ...

However, whether mitotic spindle in mammalian cells can be aligned by magnetic ... temperature and gas control for animal and human cells as well as some small model animals.

Our model offers a conceptual framework that highlights the role of spatiotemporal regulation in mitotic spindle checkpoint signalling and fidelity of chromosome segregation. Previous models ...