Our model offers a conceptual framework that highlights the role of spatiotemporal regulation in mitotic spindle checkpoint signalling and fidelity of chromosome segregation. Previous models ...

The mitotic spindle, an apparatus that segregates chromosomes ... Finally, additional experiments and a numerical model confirmed the role of transport. "The laser allowed us to make precise ...

and short spindle, which are avoided by the creation and maintenance of antiparallel microtubule overlaps. Our model can guide the identification of new, multifaceted strategies to induce mitotic ...

A prototypical example of cytoskeletal remodeling is mitotic spindle assembly, where microtubules nucleate ... We develop a torque-balance model that describes this reorganization due to dynamic ...

Meiotic errors in oocytes cause egg aneuploidy. This study shows that kinetochores employ MPS1 kinase to promote timely ...

When cells divide, microtubules -- a dynamic network of protein filaments -- form a mitotic spindle that draws the chromosomes apart and arranges them into two daughter cells. Here, plants and ...

Kinesin-5 proteins and microtubules are important components of the mitotic spindle, which segregates chromosomes in dividing cells. In a shop run by Tarun Kapoor, Ph.D., Rockefeller scientists ...

Many millions of times per day, football-shaped structures called mitotic spindles form within the body’s cells as they prepare to divide. The process is routine but mysterious, as the micro-mechanics ...

New findings from his lab published in the July 21 advance online issue of Nature demonstrate that the way the mitotic spindle—the machinery that separates chromosomes into daughter cells during ...