Our model offers a conceptual framework that highlights the role of spatiotemporal regulation in mitotic spindle checkpoint signalling and fidelity of chromosome segregation. Previous models ...

A prototypical example of cytoskeletal remodeling is mitotic spindle assembly, where microtubules nucleate ... We develop a torque-balance model that describes this reorganization due to dynamic ...

Mitotic spindles are dynamic, self-organizing, intracellular structures that are essential for cell division. Spindles are composed of proteins, cytoskeletal elements and microtubules, which are a key ...

Cell division is essential to the propagation of life. During cell division, mitotic spindles segregate duplicated chromosomes with high fidelity. Spindle structure depends on the proper polar ...

New findings from his lab published in the July 21 advance online issue of Nature demonstrate that the way the mitotic spindle—the machinery that separates chromosomes into daughter cells during ...

When cells divide, microtubules -- a dynamic network of protein filaments -- form a mitotic spindle that draws the chromosomes apart and arranges them into two daughter cells. Here, plants and ...

Many millions of times per day, football-shaped structures called mitotic spindles form within the body’s cells as they prepare to divide. The process is routine but mysterious, as the micro-mechanics ...

We then tested whether these micro-RNAs could also influence the orientation of mitotic spindles in developing mouse brains, using methodology established in Jürgen Knoblich's laboratory at IMBA.

E.R. Steuer, L. Wordeman, T.A. Schroer, M.P. Sheetz, "Localization of cytoplasmic dynein to mitotic spindles and kinetochores," Nature, 345:266-68, 1990. Michael ...