In addition, PLK1 activity at the centrosomes was found elevated in DNAJ-PKAc-expressing cells. Collectively, these data may point to accelerated mitotic progression. Direct experimental evidence of ...

The antimitotic properties of parthenolide, a natural compound with known anticancer activity, have been largely ...

In cells lacking C‐Nap1, the reduction of microtubule nucleation at centrosomes and the delay in nuclear envelop rupture in prophase probably cause mitotic defects like multipolar spindle formation ...

When cells divide, microtubules -- a dynamic network of protein filaments -- form a mitotic spindle that draws the chromosomes apart and arranges them into two daughter cells. Here, plants and ...

Changes in microtubule dynamics are essential for the formation and function of the mitotic spindle, and misregulation can lead to aneuploidy and cancer. Using in vitro reconstitution assays we show ...

Decision letter after peer review: Thank you for submitting your article "The mitotic spindle protein CKAP2 potently increases formation and stability of microtubules" for consideration by eLife. Your ...

At these locations, NuMA acts as a key structural hub in nuclear formation, spindle assembly, and mitotic spindle positioning, respectively. To achieve its variable functions, NuMA interacts with ...

The DNA initially condenses to form chromosomes which are pulled apart by a mitotic spindle. This M phase is further divided into 4 stages; prophase, metaphase, anaphase and telophase. Prophase ...

was found to be closely related to mitotic spindle formation and maintenance. It interacts with other spindle-related proteins to play a key role in maintaining the attachment of the ...

Eukaryotic cells can also undergo a specialized form of cell division called meiosis ... A structure of protein filaments called the mitotic spindle hooks on to the centromere and begins to ...