Cleveland Clinic researchers are working to improve the way we use evolutionary modeling to understand drug resistance. The ...

Furthermore, we demonstrated that the learned compensatory mechanism contributing to associative morphine tolerance requires an action of CCK at the CCK-B receptor in the L/BL amygdala.

‡ Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, Illinois 60607, United States § Center for Molecular Innovation and Drug Discovery, Northwestern ...

Watch the US Marines’ F-35B showcase its Short Takeoff and Landing (STOL) capabilities in a jaw-dropping demonstration at MCAS Miramar. This cutting-edge aircraft blends stealth, agility ...

† Diseases of the Developing World, Tres Cantos Medicines Development Campus, GlaxoSmithKline, c/Severo Ochoa, 2, 28760, Tres Cantos, Madrid, Spain ‡ Robert Robinson Laboratories, Department of ...

How sKl exerts these pleiotropic functions is poorly understood. One hurdle in understanding sKl’s mechanism of action as a “hormone” has been the inability to identify a receptor that mediates its ...

This review is the first to summarize the mechanisms of action and resistance associated with both ferroptosis and PARP inhibitors in ovarian cancer. Having established the core mechanisms of ...