Metoclopramide stimulates motility of the upper gastrointestinal tract without stimulating gastric, biliary, or pancreatic secretions. The exact mechanism of action of metoclopramide in the ...

Metoclopramide is a dopamine D 2 antagonist as well as a 5-HT 4 agonist and a weak 5-HT 3 antagonist, which leads to the stimulation of gut motility as well as an antiemetic effect.

The “H” stands for haloperidol, a potent dopamine antagonist. The “R” is for metoclopramide. This agent works both as a dopamine antagonist and to improve slowed gastrointestinal transit ...

The mechanism of sedative action of metoclopramide may be the result of a central antidopaminergic effect that metoclopramide exerts by antagonizing dopamine D2 receptors 11.

Her internist has previously recommended the combination of aspirin and metoclopramide, ... of these alternatives is their more favorable side-effect profile and more specific mechanism of action.

Box 1 Pharmacology and mechanism of action of metoclopramide. Metoclopramide is a mixed D1/D2 dopamine-receptor-blocking drug.

Metoclopramide is currently the only medication that is US FDA approved for the treatment of gastroparesis. [] It was first described by Louis Justin-Besaçon and Charles Laville in 1964 and has ...