Cellular Pathway of Methotrexate MTX affects enzymes in several important pathways, such as the folate and adenosine pathways involved in purine and pyrimidine metabolism within the cell.

Low-dose weekly methotrexate (MTX), the most widely used disease-modifying ... described above were used to analyse the effect of MTX therapy on the protective pathways in vivo. Immunoblotting of WBF1 ...

Pharmacogenomics. 2014 Mar;15(4):551-66. [4]Owen SA. et al. Genetic polymorphisms in key methotrexate pathway genes are associated with response to treatment in rheumatoid arthritis patients. Pharm J.

methotrexate; STAT1, signal transducer and activator of transcription. Collectively, these findings implied that MTX inhibits DXM-induced osteoclastogenesis through IFN-γR/STAT1 signalling pathway. In ...

Endocrinology and Metabolism, Niigata University Faculty of Medicine, Niigata, Japan iDepartment of Hematology and Rheumatology, Tohoku University Hospital, Sendai, Japan jDivision of Hematology and ...

Methotrexate may act through several pathways, such as folate antagonism, extracellular adenosine signalling, generation of reactive oxygen species, decrease in adhesion molecules, alteration of ...

Certain genetic variants may have potential to serve as biomarkers in use of methotrexate (MTX)-based ... variation that may be linked to the MTX pathway. However, impacts of genetic variation ...

Methotrexate (MTX) is a folic acid antagonist ... and this heterogeneity may be related to gene polymorphisms in related enzymes of the MTX intracellular metabolic pathway. To gain a deeper ...

Study of the association between single nucleotide polymorphisms (SNPs) of methotrexate (MTX) pathway genes and MTX-related toxicity in the treatment of hematological malignancies is popular. Here, we ...

“While the study was not originally designed to study kidney-related outcomes, the possibility of benefit of low-dose methotrexate is possible through a specific anti-inflammatory pathway,” Dr ...

Methotrexate (MTX) is a first-line medication for rheumatoid ... in RA are primarily focused on genetic variation in specific genes involved in MTX-related pathways and RA susceptibility with few ...