GTP is also a substrate for the synthesis of RNA during transcription. Purine metabolism involves the synthesis and breakdown of purine nucleotides in cells. Disorders of purine metabolism can lead to ...

By analyzing the blood and cerebrospinal fluid (CSF) of the patients, researchers have discovered critical impairments in purine metabolism and the recycling of adenosine triphosphate (ATP)-;the ...

Adenylosuccinate lyase deficiency (ADSLD) is a rare genetic disorder that affects purine metabolism, leading to various neurodevelopmental issues. Purines are essential building blocks for DNA and ...

Recent research has focused on understanding the roles of different enzymes involved in nucleotide metabolism, particularly in the context of purine and pyrimidine nucleotide biosynthesis and ...

They soon discovered, from observing the role of purines in nucleic acid metabolism, that bacterial cells require certain purines to make DNA. Hitchings hypothesized that by preventing those purines ...

The thyroid hormones are involved in the metabolism of purines and when they are deficient, the metabolism of purines is affected hence leading to higher levels of uric acid. Some of the signs of ...

A UCO team has applied the genome editing technique, which garnered a Nobel Prize in Chemistry in 2020, to unravel the ...

While the prevailing assumption in the field is that proliferating cells, including cancer cells, mostly rely on de novo synthesis to maintain their purine supply, no studies had explored this ...

More information: Joeri Bordes et al, Sex-specific fear acquisition following early life stress is linked to amygdala and hippocampal purine and glutamate metabolism, Communications Biology (2024).