image: This is the malaria parasite ribosome with mefloquine (the drug) in pink. view more Credit: Wong et al., 2017. Researchers have mapped how the malaria drug mefloquine works, providing a ...

Comparison of the mefloquine-bound and apo form (without inhibitor) of Pf80S ribosomes showed (+)-mefloquine binding within a novel eukaryotic binding site, the GTPase-associated centre (GAC) of ...

This cartoon shows the newly identified mefloquine binding site causing the changes in the ribosome's dynamics which promote read-through of the premature stop codons. The main interactions are ...

As mefloquine boosts the efficiency of aminoglycosides, the combination allows for a lower, less harmful dose of aminoglycosides. Although the positive effects of mefloquine on aminoglycosides were ...

Although the positive effects of mefloquine on aminoglycosides were already known, the current study revealed the way mefloquine binds to the ribosomes, the cell organelle where proteins are produced.

Early 2020 saw the world break into what has been described as a "war-like situation": A pandemic, caused by the severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2), the likes of ...

Scientists at St. Jude Children’s Research Hospital report that human ribosomes decode messenger RNA (mRNA) 10 times slower than bacterial ribosomes, but do so more accurately. The study “mRNA ...

Structural analysis of the human 80S/CHX complex. Human ribosomes were prepared as described 11, incubated with CHX to form the complex and the structure was determined by single particle cryo-EM ...

Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis. Nature Microbiology , 2017; 2: 17031 DOI: 10.1038/NMICROBIOL.2017.31 Cite This Page : ...