Ribosomes are tiny molecular machines inside all living cells that build proteins, and ribosome biogenesis is the complex, multi-step process by which they are made. During brain development ...

But it’s a challenge: Scientists must infect human cells with viruses, then wait for the cell’s ribosomes to start grabbing viral messenger RNA and make proteins.

New research into the interplay between aminoglycosides and the antimalarial drug mefloquine (MFQ) could have major implications for certain patients with Duchenne muscular dystrophy (DMD). The ...

Researchers have demonstrated how the antimalarial drug mefloquine can enhance the effect of aminoglycosides, another class of drugs, to override the incorrect stop signal in some genetic diseases.

The antimalarial drug mefloquine could help treat genetic diseases such as cystic fibrosis, Duchenne muscular dystrophy and some cancers.

Dave Bona is nine years into his mission of raising awareness of Mefloquine toxicity among Canada’s military veterans. The 57-year-old from St. Denis, Sask., is a disabled veteran with severe ...

The complexity of human ribosome biogenesis revealed by systematic nucleolar screening of Pre-rRNA processing factors. Mol Cell 2013;51:539-551. 26. Iouk TL, Aitchison JD, Maguire S, Wozniak RW.

Studies in yeast have provided a wealth of information about the fundamental principles of ribosome assembly, and although many features are conserved throughout eukaryotes, the larger size of human ...

In this paper, we first outline the enhancement properties of mefloquine and its mechanisms of action as an adjuvant antibiotic against multidrug-resistant bacteria. Mefloquine exhibits synergistic ...

Discover what mefloquine is and when it’s prescribed. Learn about the side effects of this anti-malarial drug.

Here, we demonstrated that the human ortholog of Dhh1p, DDX6, triggers the deadenylation-dependent decay of inefficiently translated mRNAs in human cells. DDX6 interacts with the ribosome through the ...

The human 80S ribosome is 4.3 megadaltons and is composed of 80 ribosomal proteins and 4 non-coding RNAs. Owing to the centrality of protein synthesis in life, both ribosomes and tRNAs are conserved ...