The approval of trastuzumab in 1998 has significantly improved patients ... In line with that, our review highlights the well-accepted mechanisms of action and resistance to the therapy and discusses ...

Based on the results of the phase III trials, trastuzumab can increase median survival when combined with standard chemotherapy in patients with breast cancer Mechanisms of action of trastuzumab ...

Preclinical studies have indicated several molecular mechanisms that could contribute to the development of trastuzumab resistance. Increased signaling via the phosphatidylinositol 3-kinase/Akt ...

Researchers at the University of Basel are able to test in parallel the effects of over 1,500 active substances on cell ...

Depicted are the hypothesized mechanisms of action of pharmacotherapies used in the treatment of alcohol use disorder. Acamprosate and naltrexone are approved in the United States for the ...

Structural and cellular assays and molecular dynamics simulations reveal the mechanism of action of γ-glutamyl carboxylase, which involves cholesterol and vitamin K. Protein kinase R-like ...

DelveInsight’s, “Metastatic Breast Cancer Pipeline Insight” report provides comprehensive insights about 100+ companies and ...

Imfinzi recommended for approval in European Union for the treat of adults with limited-stage small cell lung cancer ...

AstraZeneca and Daiichi Sankyo’s Enhertu (trastuzumab deruxtecan) has been approved in the US for the treatment of adult patients with unresectable or metastatic hormone receptor (HR)-positive, ...

Imfinzi recommended for approval in the EU by CHMP as first and only immunotherapy for limited-stage small cell lung cancer Recommendation based on ADRIATIC Phase III trial results which ...

Identifying and validating this biomarker helped develop drugs like Herceptin ... and physiological effects of drugs and their mechanisms of action. PD measurements generate biomarker data ...

including those with different mechanisms of action and different manufacturing and distribution constraints, on the basis of, among other things, efficacy, cost, convenience of storage and ...