Researchers characterize mechanism of action of CAR T cells Signaling properties and activity of CAR T cells are conditioned by the length of the CAR intracellular domain Date: February 14, 2019 ...

Newly discovered mechanism of T-cell control can interfere with cancer immunotherapies Date: May 3, 2024 Source: German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) Summary ...

The research team investigated the regulatory mechanisms that guide the optimal differentiation of T cells into specific lineages while inhibiting others.

Mayo Clinic researchers have discovered a key reason some cancer patients relapse after receiving chimeric antigen receptor T ...

A research team has discovered a previously unknown mechanism that could explain why many patients with aggressive B-cell lymphoma do not respond to CAR-T cell therapy in the long term. The ...

The controls depend on two mechanisms that not only avert autoimmunity but also maintain protective immunity: shaping of the T-cell repertoire in the thymus and regulation of T cells in the periphery.

A new 3D imaging technique brings the working mode of T-cell immunotherapies into live view. T-cell immunotherapy is already leading to promising results in some children with leukemia ...

The immune system plays a key role in detecting and destroying cancer cells. Cancer immunotherapy works by programming immune cells to recognize and eliminate cancer cells.

U.S. and Chinese researchers appear to have unlocked a novel way to stop T cells from attacking the body in MS and other ...

Activated T cells that carry a certain marker protein on their surface are controlled by natural killer (NK) cells, another cell type of the immune system. In this way, the body presumably curbs ...

Activated T cells that carry a certain marker protein on their surface are controlled by natural killer (NK) cells, another cell type of the immune system. In this way, the body presumably curbs ...