The question of putative mechanisms of action continues to haunt psychopharmacology. Put simply, we know these drugs work, but we have very little idea how. We make guesses based on the ...

Even though there are indications of the health-promoting and cell-protective properties of ergothioneine, the underlying mechanism of action was previously unknown. "Our analyses now finally ...

All physicians are faced with the challenge of how to help patients with no approved therapies for their diseases. What are ...

Various methods were used to analyze the characteristics, mechanism of action, and targets of cinnamaldehyde (Liu et al., 2020). Firstly, cell experiments were used to study the inhibitory effect of ...

Enzyme mechanisms are the chemical transformations, and the steps within them, generated by enzymatic action on substrates. The mechanism of enzyme catalysis is similar in principle to other types ...

Canonically, the metabolic depletion of tryptophan and/or the accumulation of kynurenine is the mechanism that defines how immunosuppressive IDO inhibits immune cell effector functions and/or ...

Annex I Parties under the Convention must provide information in their national communications under the Kyoto Protocol to demonstrate that their use of the mechanisms is supplemental to domestic ...

Researchers discovered a previously unknown mechanism that may drive tissue damage and a new target for drug discovery.

A team of scientists at the Centro Nacional de Investigaciones Cardiovasculares (CNIC), working in collaboration with ...

Copy number variants (CNVs) arise by homologous recombination (HR) between repeated sequences (recurrent CNVs) or by non-homologous recombination mechanisms that occur throughout the genome (non ...

The discovery and development of GLP-1 receptor agonists for type 2 diabetes and obesity is a bench-to-bedside success story.1 Multiple GLP-1 receptor agonists are now in clinical use, such as ...