An investigational oral targeted therapy, zipalertinib (CLN-081), demonstrated meaningful tumor responses and a manageable ...

The inclusion of hydrocortisone, progesterone, and testosterone into the cavity of β-cyclodextrin (β-CD) following two possible orientations was investigated using molecular dynamics simulations and ...

This study presents valuable findings with practical and theoretical implications for drug discovery, particularly in the context of repurposing cipargamin CIP for the treatment of Babesia spp. The ...

Motion prediction and action recognition play an influential role in the enhancement of interactions between humans and robots. We aim to predict motions and recognize actions for an interaction-based ...

Methods and results: We searched for relevant studies in PubMed, Embase, and Web of Science and included randomized controlled trials with any following outcomes of interest: clinical fracture rate, ...

The mechanism of action (MoA) of a clickable fatty acid analogue 8-(2-cyclobuten-1-yl)octanoic acid (DA-CB) has been investigated for the first time. Proteomics, metabolomics, and lipidomics were ...

Integrated network pharmacology and molecular dynamics suggest potential mechanisms involving AKT1, EGFR, and pathways like PI3K-Akt and MAPK. While further experimental validation is needed, these ...

Published: January 2000 A locus and mechanism of action for associative morphine tolerance Jennifer M. Mitchell, Allan I. Basbaum & Howard L. Fields Nature Neuroscience 3, 47–53 (2000) Cite this ...