CAR-T cells are specialized immune cells genetically modified to recognize and attack cancer cells. Researchers at Nagoya ...

Severe allergic reactions involving a cytokine storm can follow vaccination for respiratory viruses such as influenza or COVID-19, writes Irene Mavrakakis, M.D., in the summer issue of the Journal of ...

The pathogenic mechanisms of this disease are not fully elucidated; however, a role for mast cells (MCs) has been postulated ... such as chronic hypersensitivity pneumonitis (HP) and non-specific ...

An initial negative peripheral blood screen for KIT D816V does not necessarily rule out a diagnosis of systemic mastocytosis. Three hundred eighty-one patients with anaphylaxis or suspected of having ...

This signature consisted of mast cell-specific genes identified by single-cell RNA-sequencing ... we examined the change in gene expression of mast cell markers that we previously developed from scRNA ...

The researchers point to “the seminal paper” by Tetsuji Takabayashi and colleagues that showed “a significant abundance” of specific types ... off of six intraepithelial mast cells was determined as a ...

The study emphasizes that mastocytosis is not solely driven by mast cells ... that the identified proteins are specific to mastocytosis rather than a general marker of blood disorders.

Q: My doctor thinks my mast cells are activating inappropriately ... often with multiple or difficult to identify triggers. There is no specific test to diagnose MCAS, but laboratory evaluation ...

Mast cell activation syndrome ... but they’re not specific to MCAS. Still, an unexpected increase in their levels could indicate MCAS. Markers can include: Before making a diagnosis, the ...

The focus for our research is to understand the role of mast cells in health and disease and to study regulatory mechanisms for mast cell activation and mediator release. Mast cells are (in)famous for ...

If we had a way to inactivate the mast cells that respond to specific allergens, then we could stop dangerous immune responses in severe situations like anaphylaxis as well as less serious ...

In a recent study published in Neuron, researchers investigate the role of the mast-cell-specific receptor Mas-related G-protein-coupled receptor B2 (MrgprB2) in alcohol-withdrawal-induced ...