All three cases were initially evaluated with broad immunohistochemical panels that did not include specific mast cell markers. Case 2 highlights the potential immunophenotypic pitfalls of this ...

Mast cell activation syndrome ... but they’re not specific to MCAS. Still, an unexpected increase in their levels could indicate MCAS. Markers can include: Before making a diagnosis, the ...

Histidine decarboxylase is one of the enzymes of the amine precursor uptake and decarboxylation system and is known to be distributed in mast ... markers. On the other hand, large-cell carcinoma ...

If we had a way to inactivate the mast cells that respond to specific allergens, then we could stop dangerous immune responses in severe situations like anaphylaxis as well as less serious ...

In a recent study published in Neuron, researchers investigate the role of the mast-cell-specific receptor Mas-related G-protein-coupled receptor B2 (MrgprB2) in alcohol-withdrawal-induced ...

Dura matter includes peripheral nerve fibers and peripheral blood vessels. CRF binds to a specific mast cell receptor called MrgprB2, Kim said. This is the central finding of the team's study ...

Q: My doctor thinks my mast cells are activating inappropriately ... often with multiple or difficult to identify triggers. There is no specific test to diagnose MCAS, but laboratory evaluation ...

Certain immune cells backstab their cellular coworkers during allergic reactions. Mast cells, the security patrols of the immune system, can trigger allergic inflammation when they run into ...

An Ludwig-Maximilian-Universitaet (LMU) in Munich team has dissected how mast cells regulate ... This means that immune cells must be capable of detecting specific signals that interact with ...

A new statistical method called Association Plot facilitates the determination and analysis of these marker genes. Which genes are specific for a certain cell type, i.e. "mark" their identity?