All three cases were initially evaluated with broad immunohistochemical panels that did not include specific mast cell markers. Case 2 highlights the potential immunophenotypic pitfalls of this ...

Histidine decarboxylase is one of the enzymes of the amine precursor uptake and decarboxylation system and is known to be distributed in mast ... markers. On the other hand, large-cell carcinoma ...

The former also showed elevated markers of endothelial activation ... was not identified, it being a specific product of mature mast cells. These precursors may migrate into the lung since ...

If we had a way to inactivate the mast cells that respond to specific allergens, then we could stop dangerous immune responses in severe situations like anaphylaxis as well as less serious ...

Severe allergic reactions involving a cytokine storm can follow vaccination for respiratory viruses such as influenza or COVID-19, writes Irene Mavrakakis, M.D., in the summer issue of the Journal of ...

In a recent study published in Neuron, researchers investigate the role of the mast-cell-specific receptor Mas-related G-protein-coupled receptor B2 (MrgprB2) in alcohol-withdrawal-induced ...

Circulating tumor cells (CTCs) represent an important biological ... molecular characterization of CTCs can help locate organ-specific markers for the early indication of malignancies with high ...

Dura matter includes peripheral nerve fibers and peripheral blood vessels. CRF binds to a specific mast cell receptor called MrgprB2, Kim said. This is the central finding of the team's study ...

Certain immune cells backstab their cellular coworkers during allergic reactions. Mast cells, the security patrols of the immune system, can trigger allergic inflammation when they run into ...

Q: My doctor thinks my mast cells are activating inappropriately ... often with multiple or difficult to identify triggers. There is no specific test to diagnose MCAS, but laboratory evaluation ...

A new statistical method called Association Plot facilitates the determination and analysis of these marker genes. Which genes are specific for a certain cell type, i.e. "mark" their identity?