On the hand, Raf kinase inhibitor protein (RKIP) inhibits activation of MEK by Raf-1 and its downstream signal transduction, resulting in blocking the MAP kinase pathway. Moreover, Raf-1 has been ...

PA edited sections of cell-type specific functions of p38 and contributed to preparation of figures. EP edited sections of MAP kinase signaling cascade and prepared figures. KS wrote section of ...

2) Hog1 MAP kinase (MAPK) pathway One of this ... cytokines etc. via a three-tiered kinase cascade (MAPK cascade) composed of a MAPK kinase kinase (MAPKKK), a MAPK kinase (MAPKK), and a MAPK.

Mitogen-activated protein kinase (MAPK ... how alternative substrates impact on MAPK signaling regulation. The three-kinase cascade, a module conserved from yeast to humans and which comprises ...

To demonstrate the proposed approach, the c-Jun N-terminal kinase (JNK1/2) and mitogen-activated protein kinase (MAPK)-mediated phosphorylation cascade reaction was chosen as a model. After printing, ...

A typical MAPK cascade consists of at least three sequentially acting serine/threonine kinases, a MAP kinase kinase kinase (MAPKKK), a MAP kinase kinase (MAPKK) and finally, the MAP kinase (MAPK) ...

and find a striking switch in cascade utilization as cells transit from a pluripotent state to a lineage restricted state. We show that pluripotent blastula cells exhibit high Map Kinase signaling, ...

These specific sterol precursors target a single ERK-like mitogen-activated protein (MAP) kinase (MAK-1)-signaling cascade, whereas a second MAP kinase pathway (MAK-2), which is also involved in cell ...

Researchers have identified which enzymes axons use to trigger their own demise. Reporting in the January 15 Cell, first author Jing Yang and colleagues at Rockefeller University in New York found ...