eLife26d
Identification of nonsense-mediated decay inhibitors that alter the tumor immune landscape
Unless otherwise specified, qPCR reactions were set up using SsoAdvanced Universal SYBR Green Supermix (Bio-Rad, USA, Cat #1725270) following manufacturer’s instructions and performed on a QuantStudio ...
gut.bmj10d
Cholesterol biosynthesis supports the growth of hepatocarcinoma lesions depleted of fatty acid synthase in mice and humans
Objective Increased de novo fatty acid (FA) synthesis and cholesterol biosynthesis have been independently described in many tumour types, including hepatocellular carcinoma (HCC). Conclusion Our ...
The EMBO Journal7d
Chaperone-mediated autophagy regulates the metastatic state of mesenchymal tumors
Combined, these findings show that CMA displays a broad targetability on multiple steps of the EMT process and indicate a substantial role of CMA in regulating the stability of pro-metastatic and ...
eLife23d
ORMDL3 restrains type-I interferon signaling and anti-tumor immunity by promoting RIG-I degradation
State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China Center for Translational Medicine, The ...