Myc is a cancer-causing gene responsible for disrupting the normal 24-hour internal rhythm and metabolic pathways in cancer cells. The researchers found that MYC protein may affect circadian ...

Myc is a cancer-causing gene responsible for disrupting the normal 24-hour internal rhythm and metabolic pathways in cancer cells. Researchers have found that MYC protein may affect circadian ...

Myc genes are induced as primary response genes of virtually all signal transduction pathways known to be altered in cancer, including, for example, those governed by tyrosine kinase growth factor ...

Scientists at the Stanford University School of Medicine and the University of Wuerzburg, Germany, have deciphered a part of the pathway used by a well-known oncogene called Myc to exert its ...

A new review in Genes and Diseases explores the central role of MYC, a master regulatory protein, in the development and progression of cancer, spotlighting its potential as a multidimensional ...

For a cancer patient, over-expression of the MYC oncogene is a bad omen. Scientists have long known that in tumor cells, elevated levels of MYC's protein product, c-Myc, are associated with poor ...

MYC's essential role in both cancer and normal tissue development and homeostasis raises the concern that even if direct MYC inhibitors could be developed, they might be too toxic for clinical use. An ...

They have discovered that 5D4 can bind to and effectively inhibit TopBP1 from stimulating several cancer-promoting molecular pathways. Importantly, 5D4 can inhibit MYC activity in cancer. MYC has been ...

MYC proteins are important regulators of cancer cell growth, ... They showed that MYC activates a downstream pathway that chemically modifies a protein called eIF5A, ...

The MYC proteins (grey ribbons) bind to DNA and promote cancer progression. UCR researchers developed a molecule (orange pretzel-like shape) that binds to MYC, inhibiting its cancer-promoting ...

Samples tend to be a mixture of cancer and non-cancer cells, such as normal endothelial cells, fibroblasts and immune cells, that interfere with the molecular analysis of cancer cells. To cut through ...