Lubiprostone acts on type-2 chloride channels located on the apical side of gastrointestinal epithelial cells to promote electrolyte and fluid secretion into the small intestine and may also ...

Lubiprostone: Type 2 chloride channel (CCl2) activator. Chloride secretion in the intestinal lumen followed by passive diffusion of sodium and water. Nausea, headache.