Discover how sugar quietly damages your liver through dangerous mechanisms. Learn about fatty liver disease, inflammation, ...

Fact checked by Nick Blackmer For years, I trusted the words, “You’re healthy,” at my annual physicals. As someone diagnosed ...

New research identifies the liver protein PTPRD as a key regulator of metabolic liver disease. Reduced levels of PTPRD disrupt glucose and lipid metabolism, ... and impair insulin signaling.

Insulin orchestrates blood glucose levels by signaling fat and muscle cells to absorb the sugar and liver cells to stop pumping it out, so most research on insulin signaling focuses on these tissues.

"As a result, the pancreas produces more insulin to compensate ... may disrupt hunger and satiety signaling, leading to overeating and weight gain. The liver regulates fat metabolism.

Study: SARS-CoV-2 infection impairs the insulin/IGF signaling pathway in the lung, liver, adipose tissue, and pancreatic cells via IRF1. Image Credit: Eterysun / Shutterstock.com Although most ...

Adrenomedullin disrupts insulin signaling in blood vessels ... resistance is on the metabolic target organs of insulin such as liver, skeletal muscle, and adipose tissue,” the authors noted.

Ulke J, Chopra S, Kadiri OL, et al. PTPRJ is a negative regulator of insulin signaling in neuronal cells, impacting protein biosynthesis, and neurite outgrowth. J Neuroendocrinol . Published ...

In healthy individuals, insulin signaling in the brain controls appetite ... Brain-specific effects of insulin action and fat content in the liver were assessed using MRI.