Two key protein structures in the body are being visualized for the first time, thanks in part to the latest technology in ...

Scientists have discovered tumors can tap a nontraditional pathway to acquire lipoproteins—molecules that transport fat in ...

SLC35B1 transports ATP into the ER, and its structure offers potential for targeted therapies in diseases linked to ER stress ...

The accumulation of lipid-rich plaques on arterial walls eventually leads to the rupture or erosion of vulnerable lesions, triggering excessive blood clotting and leading to adverse thrombotic events.

This fundamental study combines in vitro reconstitution experiments and molecular dynamics simulations to elucidate how membrane lipids are transported from the outer to the inner membrane of ...

1989, 1991, Bozza & Weller 2001). Moreover, PAF but not its precursor and metabolite, lyso-PAF, that shares the lipid structure of PAF but has no receptor agonistic activity (Prescott et al. 2000), ...

The liver has a unique structure, especially at the level of individual cells. Hepatocytes, the main liver cells, release bile into tiny channels called bile canaliculi, which drain into the bile duct ...

Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to ...

Successful drug development for bioactive lipid targets requires a deep knowledge of the biology and pathobiology ... and metabolic profiles into the drug structure (Fig. 2).

The findings have been published in Communications Chemistry. Lipid nanoparticles (LNPs) came to prominence for the delivery of RNA with the success of the Moderna and Pfizer BioNTech COVID-19 ...

Scientists have developed a method for analysing the structure of lipid nanoparticles that could be used to improve vaccine and drug delivery, targeting a wide range of health issues. A team led by ...

We report on the aggregation and dynamic behavior of excipients in type I and surfactant-free lipid formulations containing water-soluble cosolvents. Specifically we have investigated the internal ...