Nanotechnology may be the key to opening the gate of the blood brain-barrier, providing a significant advantage over currently used drug delivery strategies for brain cancers and other CNS disorders.

As time goes by, our bodies change, you know, even the brain. A major change is how brain structure seems to shrink with age. Studies show that this happens at both large and small levels inside. You ...

Here we use cryogenic electron microscopy to determine the structure of TbAQP2 from Trypanosoma brucei, bound to either the substrate glycerol or to the sleeping sickness drugs, pentamidine or ...

Spatial metabolomics is transforming our understanding of microbial systems by uncovering the localized molecular dynamics ...

Large yeast clusters generate natural circulatory flows through metabolic activity to bypass diffusion limits by Justin Jackson, Phys.org edited by Sadie Harley, reviewed by Robert Egan Editors' notes ...

The majority of drugs, prescriptive, nonprescriptive, or illicit are transferred across the placenta by passive diffusion owing to their small lipid-soluble molecules. [16] ...

This process has been shown to directly involve interactions between proteins and lipid surfaces when the latter are present. Despite this importance, the molecular mechanisms of lipid-induced amyloid ...

Substrate supported planar lipid bilayers (SPBs) are versatile models of the biological membrane in biophysical studies and biomedical applications. We previously developed a methodology for ...

A Pluronic-functionalized silica–lipid hybrid (Plu-SLH) microparticle system for the oral delivery of poorly water-soluble, weak base drugs is reported for the first time. A highly effective Plu-SLH ...

shown that the impact of conduction through the liquid condensate is small when the steam mass fraction is less than 70%. With the increasing of the steam mass fraction, the film conduction is more ...