This article examines viral and non-viral vectors in gene therapy, highlighting their mechanisms, advantages, and limitations ...

The CRISPR-Cas9 system offers groundbreaking genome editing capabilities, yet off-target cleavage raises concerns about ...

while there has been less emphasis on the replicating viral vector constructs. Nucleic acid-based approaches include DNA and mRNA vaccines, often packaged into nanocarriers such as virus-like ...

Several ASOs have been on the market since the first one – fomivirsen for a viral eye infection that affects patients ... negatively charged molecule that does not naturally cross cells easily. Lipid ...

The T cells are activated with cytokines to stimulate cell division, and a viral vector is then used to engineer the ... “Non-viral vectors, particularly mRNA-laden lipid nanoparticles, offer a ...

Yan, “Toxicity of cationic lipids and cationic polymers in gene delivery ... Fernandes, “Chitosan/pDNA nanoparticles as non-viral vectors in gene therapy: strategies to improve transfection efficacy,” ...

These advancements aim to provide safer and more effective non-viral mRNA delivery systems. 6 For liposomes, research focuses on improving stability and extending circulation time in the body. Adding ...

View Full Profile. Learn about our Editorial Policies. Genetic medicines could treat certain diseases, however, the current delivery systems available—viral vectors and lipid nanoparticles (LNPs)—pose ...