A phase II study of single-agent sunitinib after failure of standard mCRC therapy found median overall survival (OS) to be 10.2 and 7.1 months in patients with bevacizumab-untreated and ...

Mechanism of action describes the process by which a molecule, such as a drug, functions to produce a pharmacological effect. A drug’s mechanism of action may refer to its effects on a ...

During embryonic development, thousands of cells divide and move collectively to sculpt the main body axes. Understanding the mechanisms that coordinate this collective behavior remains a ...

This important study looks into the effect of exogenous CoA on the response of TLR4-activated macrophages. Specifically, CoA enhances the LPS response by examining metabolomics, 13C tracing, and ...

Evidence was obtained that this action was mediated by CD95-dependent and -independent mechanisms. Vorinostat is the HDAC inhibitor that has the most extensively advanced clinical applications.

In clinical trials, patients treated with Avastin plus chemotherapy, like 5-FU, irinotecan, leucovorin, and oxaliplatin, survived about five months longer than patients treated with the ...