For the girl (a carrier of leptin variant G59S), the dose was increased to 0.15 mg/kg on day 2 of treatment, and tapered down starting on day 264, with an ending dose of 0.07 mg/kg.

Anil Oza is STAT’s 2024-2025 Sharon Begley Science Reporting Fellow. You can reach Anil on Signal at aniloza.16. The hormone leptin was discovered 30 years ago to much fanfare. Scientists hoped ...

Leptin levels tend to peak between midnight and dawn, making you less hungry. That makes sense because there’s not much you can do about being hungry when you’re asleep in the middle of the night.

Leptin, produced primarily by fat cells, typically signals the brain when enough food has been consumed, helping to regulate energy and appetite. But in some individuals with obesity, ...

Leptin is the satiating hormone. It is naturally secreted by your fat cells to suppress appetite; it's your brain's cue to stop eating. When there's a leptin deficiency, ...

Ghrelin and leptin are two hormones that are of great interest in appetite regulation. Leptin is commonly considered anorexigenic (i.e., appetite suppressant), while ghrelin is orexigenic (i.e ...

A new study in mice describes novel neurocircuitry between midbrain structures that control feeding behaviors that are under modulatory control by leptin, a hormone made by body fat. Since the ...

High leptin levels promote a low-grade systemic inflammatory state. If you have obesity, there are a number of underlying health issues that make it more difficult for you to fight off a COVID-19 ...

Researchers discover a cause of leptin resistance—and how to reverse it . Rockefeller University. Journal Cell Metabolism DOI 10.1016/j.cmet.2025.01.001 ...

Leptin’s hunger-suppressing effects are mediated by the hypothalamic–pituitary–adrenocortical axis in rodents. Proceedings of the National Academy of Sciences , June 18, 2019; DOI: 10.1073 ...

In leukemic mice, fasting reduces the development of acute lymphoblastic leukemia, but not acute myeloid leukemia, via upregulation of leptin receptor expression and signaling in the leukemic cells.