Scientists have developed a hydrogel “rest stop” that shields cancer-fighting T cells, delaying their exhaustion and boosting ...

As T cell exhaustion is led by a robust system of inhibitory pathways, under the activation of other co-inhibitory pathways such as Gal-9/Tim-3, T cells may undergo this differentiation regardless of ...

Poly(lactic acid) (PLA), a biobased and biodegradable plastic, has garnered substantial attention due to its environmental benefits. However, the inherent brittleness, limited functionality, and ...

Remodeling the Tumor Microenvironment via Metal-Phenolic Network-Coated Poly (lactic acid- co-glycolic acid) Nanoparticles for Inducing Multimodal Combination Therapy in Non-Small Cell Lung Cancer ...

Using CD34 lineage-tracing mice and single-cell RNA sequencing, we identified a Tfh cell population derived from CD34-lineage CD4 + T cells. Untargeted and targeted metabolomics revealed distinct ...

Capstan Therapeutics scientists demonstrate that lipid nanoparticles can engineer CAR T cells within the body without laboratory cell manufacturing and ex vivo expansion.