They are chemically characterized by a β-lactam ring in their chemical structure. The drugs are used against a wide range of bacterial infections, including Gram-positive and Gram-negative species.

That’s a concern because the chemical structure of ezetimibe contains what’s known as a beta-lactam ring. FDA safety experts pay attention to this because many beta-lactam drugs, particularly ...

Figure 1. Zinc inactivates beta-lactam antibiotics by helping an enzyme attack the drug’s reactive ring. Zinc holds a water molecule in place, helping break open the ring. Once it’s open, the drug is ...

The work, which created an enzyme from an iron-containing muscle protein to catalyse lactam synthesis, could offer a simpler, cheaper and more efficient way to make them. Lactams are ring-shaped ...

Homologation of the lactam ring allows the capping group modification to decrease and delocalize the molecule’s lipophilicity, reducing the metabolic rate at secondary sites. The effect of deuteration ...

According to the Food and Drug Administration (FDA), non-antibacterial compounds containing a beta-lactam ring could have similar sensitizing and allergenic properties as beta-lactam antibacterial ...

Cross-reactivity within the penicillin class of antibiotics can be conferred through the shared beta-lactam ring that is present in all semisynthetic penicillins and in benzylpenicillin. 13 ...

Among these, the expression of β-lactamases is the most common mechanism found in various bacteria resistant to β-lactams (Lingzhi et al., 2018). β-Lactamases inactivate β-lactam antibiotics by ...