Sarclisa is currently approved in three indications in the EU, across different lines of therapy in adult patients with relapsed and/or refractory (R/R) MM and with NDMM who are not eligible for ...

Here we investigate the N162 glycan’s role in FcγRIIIa structure, antibody-binding affinity and NK cell ADCC. ... (Fischer Scientific) and storage at 4 °C. Following expression in these media, the ...

The structure of the teleost Immunoglobulin M core provides insights on polymeric antibody evolution, assembly, and function. Nature Communications, 2023; 14 (1) DOI: 10.1038/s41467-023-43240-z; ...

More information: Mengfan Lyu et al, The structure of the teleost Immunoglobulin M core provides insights on polymeric antibody evolution, assembly, and function, Nature Communications (2023). DOI ...

The study “The structure of the teleost Immunoglobulin M core provides insights on polymeric antibody evolution, assembly, and function” was published in Nature Communications and can be found ...

Figure 2 Structure prediction.(A) Selecting the acceptor human framework by framework shuffling.(B) Binding of hVH0VL0-hIgG1 to cell surface human PD-L1 was determined by FACS.(C) mVH structure (D) ...

Each patient had a characteristic hypertrophic phenotype and Perugini grade 2 cardiac uptake on technetium-99m–labeled 3,3-diphosphono-1,2-propanodicarboxylic acid scintigraphy.

NI006 is a recombinant human anti-ATTR monoclonal IgG1 antibody that was generated through comprehensive immune repertoire analyses of memory B-cell complement obtained from healthy older persons ...