Plant phototropism—directional growth in response to light—serves as a key adaptive mechanism, optimizing photosynthesis and ...

The ability of protein kinases to transfer a phosphate group to target proteins plays an important role in many cellular ...

Silencing of aurora kinase A results in less phosphorylation of p53 at Ser315, greater stability of p53 and cell-cycle arrest at G2-M. Cells depleted of aurora kinase A are more sensitive to ...

Comparison with various high-throughput phosphorylation mapping studies showed limited overlap between the kinase phosphorylation interactions and kinase protein–protein interactions, suggesting ...

An unexplored kinase in heart muscle cells may be a good target to treat heart failure, a disease that is only incrementally delayed by existing therapies. Failing human hearts showed reduced ...

video: Information on phosphorylation included in the database was obtained through the kinase- interacting substrate screening method (A), kinase-oriented substrate screening method (B), and ...

ING5 inhibits aerobic glycolysis of lung cancer cells by promoting TIE1-mediated phosphorylation of pyruvate dehydrogenase kinase 1 at Y163 ...

Discover how next-generation kinase inhibitors are transforming clinical therapy byovercoming resistance and enhancing treatment efficacy.

Ibrutinib is an irreversible inhibitor of Bruton's tyrosine kinase (BTK) and is effective in chronic lymphocytic leukemia (CLL). Resistance to irreversible kinase inhibitors and resistance associat ...

Photys Therapeutics Debuts with $75 Million Series A Funding to Advance New Class of Bifunctional Molecules for Precision Phosphorylation to Modulate and Repair Disease-Driving Proteins ...

Thus, the identification of CDK phosphorylation targets (substrates) is an important goal in the search for cancer therapeutics. However, despite many advances, identifying protein kinase substrates ...