The ability of protein kinases to transfer a phosphate group to target proteins plays an important role in many cellular ...

Small-molecule protein kinase inhibitors are widely used to elucidate cellular signaling pathways and are promising therapeutic agents. Owing to evolutionary conservation of the ATP-binding site, ...

Lipid kinases are enzymes that play a critical role in both cell signaling and membrane trafficking by phosphorylating lipid ...

Being cut off in traffic, giving a presentation or missing a meal can all trigger a suite of physiological changes that allow the body to react swiftly to stress or starvation. Critical to this "fight ...

Small-molecule kinase ligands can induce proteasome-dependent degradation of kinases; one example of this is observed for inhibitors of maternal embryonic leucine zipper kinase (MELK) 187.

In the study, we focused on two small molecule kinase inhibitors that are equipotent in isolated enzyme assays but show difference in their target residence times, i.e., for how long a single ...

Small molecule activates key kinase By boosting the activity of PI3Kα, the compound UCL-TRO-1938 spurs nerve regeneration in rats by Bethany Halford ...

Lipid kinases are enzymes that play a critical role in both cell signalling and membrane trafficking by phosphorylating lipid ...

Researchers now report that a small-molecule kinase inhibitor can reduce neurotoxicity in cell and mouse models of amyotrophic lateral sclerosis (ALS) by forcing neurons to jettison aggregated ...