A research team has identified a molecular mechanism that coordinates the operation of the N-methyl-D-aspartate (NMDA) ...

ALPK3 (α protein kinase 3) is an atypical kinase highly expressed in human and murine hearts. Biallelic loss‐of‐function mutations in ALPK3 lead to pediatric cardiomyopathy. The specific stages at ...

Thymidine kinase 2 deficiency (TK2d ... Researchers hope it helps mtDNA and cell function. Although not FDA approved, you may be able to get it in a clinical trial. Some doctors also prescribe ...

Thymidine kinase 2 deficiency is an ultra-rare ... that supports mitochondrial DNA replication resulting in increased or stabilized mitochondrial function in patients with TK2d. Pre-clinical data ...

“Komander and his team deserve high praise for this work.” PINK1, a ubiquitin kinase that causes early onset Parkinson’s disease when mutated, functions as an early warning system for faltering ...

Greatwall, a conserved MAST-like kinase with crucial mitotic entry functions, is curiously absent in worms. Here, the single canonical MAST kinase family member KIN-4 is shown to fulfill this role and ...

This modification regulates the activity, localization, and function of proteins, ultimately influencing various cellular activities. Disruption in these kinase-substrate interactions is often ...

the spleen has to increase its function. Therefore, it becomes enlarged. This condition is painless. A doctor can look at the kinase deficiency symptoms to diagnose the problem. Additionally ...

and contribute to an expanding view of kinase function in both health and disease. Early work on allostery and kinase function relied heavily on the tried-and-trusted approaches of biochemistry and ...

Together, these results identify a function of PKM2 as a histidine kinase, and illustrate the importance of enzyme crosstalk as a regulatory mode during metabolic reprogramming and tumorigenesis. The ...

These pseudo-kinases despite being catalytically inactive, perform numerous non-canonical kinase functions through their inactive ATP binding domain. A sub-family of these pseudo-kinases are the ...