A rare SIK3 gene mutation may explain why some people need less sleep yet maintain optimal cognitive function and physical health.

In collaboration with scaffolding proteins that bind the three-kinase cascade together, and as a result of its dual-specificity, MEK1/2 can either function as a single switch through rapid double ...

This modification regulates the activity, localization, and function of proteins, ultimately influencing various cellular activities. Disruption in these kinase-substrate interactions is often ...

The goals are to get a better handle on kinase function, identify new kinase inhibitors for cancer therapy, and screen candidates for side-effects on other pathways. To help researchers get the ...

Finally it should be mentioned that it was found that the catalytically inactive mutant (K42A) of DAP-kinase functions in a trans-dominant negative manner. This possibility was examined by ...

This modification regulates the activity, localization, and function of proteins, ultimately influencing various cellular activities. Disruption in these kinase-substrate interactions is often ...

A creatine kinase test is a blood test that measures levels of an enzyme called creatine kinase. This enzyme supports energy production in the body and is particularly important for muscle and ...

Pyruvate kinase deficiency is inherited as an autosomal recessive trait and is caused by loss-of-function mutations in PKLR. The prevalence of homozygous pyruvate kinase deficiency is estimated at ...

But their efforts are focused on inhibiting CDK6's kinase function. We have shown that CDK6 has an additional, kinase-independent mode of action that is responsible for the uncontrolled cell ...

the spleen has to increase its function. Therefore, it becomes enlarged. This condition is painless. A doctor can look at the kinase deficiency symptoms to diagnose the problem. Additionally ...