The mystery of how cancers build up resistance mechanisms and evade the treatments that should have destroyed them is a ...

Treatment Response Prediction: In advanced breast cancer patients receiving Cyclin-dependent kinase inhibitors (CDKi), specific residue concentration patterns predicted 98 % of responders (N = 33), ...

Lipid kinases are enzymes that play a critical role in both cell signaling and membrane trafficking by phosphorylating lipid ...

A research team led by Prof. Liu Qingsong from the Hefei Institutes of Physical Science of the Chinese Academy of Science has ...

Mass spectrometry and kinase assays reveal that SAS-6 is phosphorylated at its C-terminus in cells and in vivo, with CDK-1 identified as a direct kinase. This phosphorylation inhibits SAS-6 phase ...

PURPOSEMDM2, a negative regulator of the TP53 tumor suppressor, is oncogenic when amplified. MDM2 amplification (MDM2amp) is mutually exclusive with TP53 mutation and is seen in 6% of patients with ...

NMR assays of the δ1 tail with the kinase domain in trans or cis, via segmental isotopic labeling, revealed that the interaction between the kinase domain and δ1 tail is dependent on phosphorylation ...

E, In vitro kinase assay using (γ- 32 P) ATP, recombinant AMPK, full-length recombinant β-arrestin-1-wild-type (WT)/S330A with or without phosphatase. rhACE2 (recombinant human angiotensin-converting ...