Patients with type 2 diabetes mellitus are at a higher risk of developing heart failure compared with the healthy population. In recent landmark clinical trials, sodium-glucose co-transporter 2 (SGLT2 ...

Cardiovascular disease (CVD) is the predominant cause of death globally, accounting for ≈30% of deaths each year. 1 The prevalence of CVD among adults (aged ≥20 years) in the United States was 48.6% ...

The mechanism of action (MoA) of a clickable fatty acid analogue 8-(2-cyclobuten-1-yl)octanoic acid (DA-CB) has been investigated for the first time. Proteomics, metabolomics, and lipidomics were ...

During embryonic development, thousands of cells divide and move as one. Understanding the mechanisms that coordinate this collective behavior remains a significant challenge in biology and the ...

The switch from fetal γ-globin to adult β-globin is controlled by BCL11A. Genetic manipulation of BCL11A improves disease outcomes by turning γ-globin expression back on to compensate for ...

The collaboration is also expected to support Allarity in potential future efforts to pursue marketing approval for stenoparib, and to further clarify its mechanism of action in both the Company’s ...

When benefit and plan data is accessible and structured for use by these tools, we move from giving information to enabling action. Navigation becomes personalized and proactive. 2.

The prevention of unplanned pregnancies is a global problem that requires immediate attention. The livelihoods of both men and women are affected by this issue. The best way to prevent unplanned ...

Mohamed, J., et al. (2016) Mechanisms of Diabetes-Induced Liver Damage The Role of Oxidative Stress and Inflammation ... 45 mg/kg, intraperitoneally). Over a 4-week experimental period, the effects of ...

Over a 4-week experimental period, the effects of SGT (Sitagliptin, 100 mg/70 kg BW), MoLE (Moringa oleifera leaves extract, 200 mg/kg BW), and SGT + MoLE (integrative therapy of sitagliptin, 50 mg/70 ...