Assessing efficacy of intrathecal chemotherapy in patients with leptomeningeal metastases: A systematic review and meta-analysis. Shree Rath , Osama Ahmad , Belal Mohamed Hamed , Fatima Sajjad , ...

The German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia (GMALL) B-ALL/NHL 2002 protocol achieved a 3-year overall survival and progression-free survival of 73% in adult patients ...

Similarly, an intrathecal injection into CSF allows chemotherapy medications to access your brain and spinal cord, bypassing the protective blood-brain barrier.

Intrathecal chemo is used most often to treat cancers that involve the brain or spinal cord or have a high risk of spreading there. For example, some forms of leukemia and lymphoma are more likely ...

A total of 76% of the patients achieved 5-year survival and 30% experienced grade 3 or 4 infections. High-dose methotrexate (HD-MTX) with the modified Bonn protocol including intrathecal therapy ...

ABSTRACT. Background: Intrathecal chemotherapy is a local therapeutic modality used for treatment of leptomeningeal metastases.However, the techniques currently used, i.e. repeated lumbar puncture and ...

Intrathecal chemotherapy and high-dose methotrexate is a common treatment for acute lymphocytic leukaemia and Burkitt lymphoma, and high-dose methotrexate was added as consolidation therapy in an ...

Intrathecal. For this type of chemotherapy, your doctor uses a needle or long-term catheter and port to inject medicine into the cerebrospinal fluid. This fluid surrounds your spinal cord and brain.

The most common treatment is the chemotherapy drug methotrexate. You might have this: as an injection into the fluid around your spinal cord - this is intrathecal chemotherapy; as an infusion into ...

Accordingly, the patient received an intrathecal injection of pemetrexed (dose 30 mg) every 2-3 months, 2-3 times per course (4-6 days each time), and continued to receive a double dose of osimertinib ...