Although the interphase nuclear envelope is continuous with the endoplasmic reticulum, it is distinct from the endoplasmic reticulum in both form and composition. In metazoans, the nuclear ...

A new role for BAF in nuclear envelope repair through recruitment of nuclear transmembrane proteins during interphase.

Importantly, nuclear envelope rupture was transient, as shown by the redistribution of the NLS–GFP signal, indicating that cells can restore nuclear membrane integrity during interphase.

Using this approach, the protein CTDNEP1 was identified as a key nuclear stability factor. To study nuclear membrane rupture during interphase, Dr. Hatch's team developed a nuclear membrane rupture ...