The cell must also pass through a series of checkpoints that ensure conditions are favorable for division. In order to move from one phase of its life cycle to the next, a cell must pass through ...

Thus, abrogation of cell cycle checkpoints, before DNA repair is complete, can activate the apoptotic cascade, leading to cell death. Now in clinical trials are a series of targeted agents that ...

The cell cycle relies on ubiquitin and the SCF complex ... However, this complex requires activation by a protein called NEDD8. During interphase, a range of proteins bind to the SCF complex ...

G1, S and G2 phases are all cumulatively referred to as interphase involving the ... for passing important points in the cell cycle, called checkpoints. These checkpoints are present at the ...