In a paper published in Diabetes, they show that, in Type 1 diabetes patients, verapamil prevented the decline of the hormone insulin-like growth factor 1, or IGF-1, as compared to controls who did ...

IGF-1R has 70% homology to IR, with which it shares some signaling pathways. As a consequence of the close homology of IR and IGF-1R, hybrid receptors can be formed by an insulin alpha-beta ...

Serum IGF-I, IGFBP-1, IGFBP-3 and insulin levels seem unrelated to endometrial cancer risk. Among users of HRT, increasing IGFBP-1 levels seem to increase endometrial cancer risk.

Insulin Growth Factor (IGF) pathway is involved in endocrine, paracrine and autocrine control and it mediates its effect through IGF-1R. Elevated IGF-1 has been associated with increased risk of lung ...

Plasma levels of insulin-like growth factor 1 (IGF-1) could give clinicians a better understanding of whether a patient with Parkinson disease (PD) is likely experiencing nonmotor symptoms of the ...

Specifically, they analyzed 265 SNPs linked to blood levels of IGF-1, and four SNPs for insulin-like growth factor binding protein 3 (IGFBP-3), which binds most of the IGF-1 found in the blood.

Data show that PALSONIFY was well tolerated and IGF-1 levels remained stably controlled during long-term open label ...

IRF1 was also found to be associated with the impairment of the insulin/IGF signaling pathway. Previous studies have linked the expression of IRF1 with male sex, older age, diabetes, and COVID-19.

These results add an additional, mechanistic aspect to further explain how the decades-old blood pressure medication verapamil can preserve beta cell function in Type 1 diabetes patients by affecting ...