The MAP kinase and PI3 kinase signaling pathways are among the best ... via activation of p70S6 kinase. The insulin (IR) and insulin-like growth factor-1 (IGFR) receptors activate both MAP and ...

Two well known factors are tumor hypoxia and overexpression of epidermal growth factor receptor (EGFR), a molecule that triggers signal pathways to regulate cell growth and contribute to oncogenesis.

BACKGROUND: Recent studies have highlighted the deleterious role of high phosphate intake in hypertension by means of ...

Enthera Pharmaceuticals ("Enthera"), a clinical-stage biotech company developing a first-in-class antibody therapeutic targeting the Insulin Growth Factor Binding Protein 3 (IGFBP3)/TMEM219 pathway ...

Insulin-like growth factor 1 (IGF1) is a polypeptide hormone structurally ... It activates both the mitogen-activated protein (MAP) kinase and PI3K signaling pathways, acting in almost every tissue in ...

Growth Hormone-Releasing Peptide-2 (GHRP-2) is a synthetic hexapeptide that has garnered significant attention in the ...

Abstract:        Obesity, a growing global issue, has been closely associated with an increased risk of various cancers, especially breast cancer. El ...

Thus, in HR + /HER2 + breast tumors a vicious cycle is established between ER genomic and non-genomic mechanisms of action and the growth factor ... therapy ER/GF signaling pathways and ...

Identifying proteomic signatures of insulin resistance in fasting muscle offers insights for personalized type 2 diabetes ...

Pro-inflammatory signaling molecules in MS cause problems with the growth and development of myelin-making cells in the brain ...

ACVR2A downregulation disrupts the TCF7/c-JUN pathway, impairing trophoblast invasion and proliferation in pre-eclampsia, revealing a genetic susceptibility-associated mechanism of placental ...

Update: Prime Biome Reviews Reveal Groundbreaking Gut Microbiome, Skin Barrier, and Dysbiosis Correction Benefits Backed by New Clinical Findings WASHINGTON, PA / ACCESS Newswire / June 5, 2025 / ...