News Medical3d
Targeting ELK3 could offer new therapy for rheumatoid arthritis
Rheumatoid arthritis (RA) is an inflammatory arthritis characterized by chronic joint inflammation, cartilage degradation, and bone erosion.
Armed robbery in Revesby5d
ELK3's Role in Rheumatoid Arthritis Synoviocyte Death
Rheumatoid arthritis (RA) is an inflammatory arthritis characterized by chronic joint inflammation, cartilage degradation, and bone erosion. ELK3 is a ...
Medscape5d
Identification of a novel protein binding to hepatitis C virus core protein
The cells were used for subsequent Mammalian Matchmaker two-hybrid assays, Western blots and intracellular localization of ACY3. The plasmids pM-core and pVP16-ACY3 were constructed and confirmed ...
eLife1d
Enalapril mitigates aging by targeting antioxidative genes via phosphorylated Smad1/5/9
In summary, enalapril significantly mitigated multiple pathological markers associated with aging, including lipid droplets, amyloid, glycogen deposition, and fibrosis, in the brain, kidneys, liver, ...
eLife2d
Maturation and detoxification of synphilin-1 inclusion bodies regulated by sphingolipids
Due to proteostasis stress induced by aging or disease, misfolded proteins can form toxic intermediate species of aggregates and eventually mature into less toxic inclusion bodies (IBs). Here, using a ...
gut.bmj6d
Epigenetic modification of MiR-429 promotes liver tumour-initiating cell properties by targeting Rb binding protein 4
The gene expressions affected by miR-429 were determined by arrays. Co-immunoprecipitation was used to study interactions among retinoblastoma protein (RB1), Rb binding protein 4 (RBBP4) and E2F ...