Elevated immunoglobulin free light chain (FLC) level and abnormal FLC ratio are commonly seen in multiple myeloma (MM) and have prognostic implications. We hypothesized that presence of ...

However, it is well documented that plasma cells also produce and secrete Ig-free light chain (IgLC) in excess over Ig heavy chains 5,6,7,8. Turnover studies in humans demonstrated that only 60% ...

Renal failure in multiple myeloma typically occurs when the kidneys fail to filter waste products from the blood, leading to ...

Systemic immunoglobulin light-chain (AL) amyloidosis is characterized by deposition of amyloid fibrils of light chains produced by clonal CD38+ plasma cells. Daratumumab, a human CD38-targeting ...

Care of patients with systemic immunoglobulin light chain (AL) amyloidosis has undergone transformative changes, leading to marked, steady progress in outcomes for patients over the past four decades.

really small… this “M-protein” the dominant-overpowering antibody (immunoglobulin) is composed of two different kinds of molecules, the two “chains”; Heavy Chain Molecules and Light Chain Molecules.

Light chain multiple myeloma is a subtype of multiple ... The type depends on the immunoglobulin that a myeloma cell produces, also known as antibodies or M-proteins. According to the ...

This initiative celebrates important research from the School of Medicine faculty members. Recently, his study “Immunoglobulin light chains generate pro-inflammatory and profibrotic kidney injury,” ...