Imatinib is approved by the FDA for the treatment of chronic myeloid leukemia (CML) and gastrointestinal stromal tumors (GIST). Imatinib potently inhibits a select set of tyrosine kinases at ...

Expertise from Forbes Councils members, operated under license. Opinions expressed are those of the author. A lot of organizations like to say publicly that “the client comes first.” ...

Structure-based drug design is the design and optimization of a chemical structure with the goal of identifying a compound suitable for clinical testing — a drug candidate. It is based on ...

Gene-editing specialist Editas Medicine has halted development of its lead clinical programme for congenital eye disorders after it generated lacklustre results in a phase 1/2 trial. The ...

including generic versions of products like Merz' multiple sclerosis therapy Ampyra (dalfampridine), Novartis' cancer drug Gleevec (imatinib), and Amgen's Sensipar (cinacalcet) for ...

Find more information on the Altmetric Attention Score and how the score is calculated. Imatinib, a drug used for the treatment of chronic myeloid leukemia and other cancers, works by blocking the ...

Metastasis of cancers accounts for almost all cancer-related deaths. In this study, we report a PEGylated nanostructured platform for coadministration of doxorubicin (DOX) and imatinib (IMT) intended ...

It's also important to understand that all of the TKIs can harm a fetus if taken during pregnancy. Imatinib (Gleevec) was the first drug to specifically target the BCR-ABL tyrosine kinase protein, and ...

Seats on the PLO’s various decision making bodies, including the Executive Committeee (EC), the 200 member Central Council (CC), and the larger Palestine National Council (PNC), are shared by these ...

But tumour-agnostic drugs may be of great importance for future cancer treatment. Illustration: Sylvia Stølan Following the introduction of imatinib almost 20 years ago, we have become accustomed to ...