To cope with hypoxia, tumor cells have developed a number of adaptive mechanisms mediated by hypoxia-inducible factor 1 (HIF-1) to promote angiogenesis and cell survival. Due to significant roles of ...

Obstructive sleep apnoea (OSA) is recognised to be a potent risk factor for hypertension, coronary heart disease, strokes and heart failure with a reduced ejection fraction. However, the association ...

Group 2 (due to left-sided heart disease) and group 3 (secondary to chronic lung disease or alveolar hypoxia) are the most prevalent forms of PH. 2 Group 4 PH is related to obstruction of the ...

New AMPK Program Targets Aging and Muscle Regeneration In addition to its lead candidates, Biolexis will continue development of BLX-08155, an isoform-specific AMPK activator identified for its ...

Background It is unknown whether lesions in human TB are hypoxic or whether this influences disease pathology. Human TB is characterised by extensive lung destruction driven by host matrix ...

Abstract. Defining the hypoxic thresholds that trigger blood-brain barrier disruption: the effect of age. Chronic mild hypoxia (CMH; 8% O 2) triggers transient blood-brain barrier (BBB) disruption, an ...

The system could efficiently alleviate hypoxia in tumor environments for up to 7 days, meeting the “once injection, repeat irradiation” strategy and enhanced PDT efficacy. Besides, the generated ...

Our study identifies hypoxia-driven histone lactylation as a potential target to block immunosuppressive neutrophils and boost the effects of immunotherapy in glioblastoma and in other cancer settings ...